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Further information

TOLERANCE
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Sanchez-Fueyo, Alberto


Publications

Impact Factor

Cites


ReferenceImpact FactorCitesQuartile
Martínez-Llordella M, Puig-Pey I, Orlando G, Ramoni M, Tisone G, Rimola A, Lerut J, Latinne D, Margarit C, Bilbao I, Brouard S, Hernández-Fuentes M, Soulillou JP, Sánchez-Fueyo A. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant. 2007 Feb;7(2):309-19. PubMed PMID: 17241111.
7.338
286
1
Martínez-Llordella M, Lozano JJ, Puig-Pey I, Orlando G, Tisone G, Lerut J, Benítez C, Pons JA, Parrilla P, Ramírez P, Bruguera M, Rimola A, Sánchez-Fueyo A. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. J Clin Invest. 2008 Aug;118(8):2845-57. doi: 10.1172/JCI35342. PubMed PMID: 18654667; PubMed Central PMCID: PMC2483684.
11.864
255
1
Benítez C, Londoño MC, Miquel R, Manzia TM, Abraldes JG, Lozano JJ, Martínez-Llordella M, López M, Angelico R, Bohne F, Sese P, Daoud F, Larcier P, Roelen DL, Claas F, Whitehouse G, Lerut J, Pirenne J, Rimola A, Tisone G, Sánchez-Fueyo A. Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients. Hepatology. 2013 Nov;58(5):1824-35. doi: 10.1002/hep.26426. Epub 2013 Sep 19. PubMed PMID: 23532679.
14.679
223
1
Lerut J, Sanchez-Fueyo A. An appraisal of tolerance in liver transplantation. Am J Transplant. 2006 Aug;6(8):1774-80. Review. PubMed PMID: 16889539.
7.338
162
1
Sánchez-Fueyo A, Strom TB. Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs. Gastroenterology. 2011 Jan;140(1):51-64. doi: 10.1053/j.gastro.2010.10.059. Epub 2010 Nov 9. Review. PubMed PMID: 21073873; PubMed Central PMCID: PMC3866688.
17.373
159
1
Bohne F, Martínez-Llordella M, Lozano JJ, Miquel R, Benítez C, Londoño MC, Manzia TM, Angelico R, Swinkels DW, Tjalsma H, López M, Abraldes JG, Bonaccorsi-Riani E, Jaeckel E, Taubert R, Pirenne J, Rimola A, Tisone G, Sánchez-Fueyo A. Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J Clin Invest. 2012 Jan;122(1):368-82. doi: 10.1172/JCI59411. Epub 2011 Dec 12. PubMed PMID: 22156196; PubMed Central PMCID: PMC3248302.
11.864
153
1
Sánchez-Fueyo A, Whitehouse G, Grageda N, Cramp ME, Lim TY, Romano M, Thirkell S, Lowe K, Fry L, Heward J, Kerr A, Ali J, Fisher C, Lewis G, Hope A, Kodela E, Lyne M, Farzaneh F, Kordasti S, Rebollo-Mesa I, Jose Lozano J, Safinia N, Heaton N, Lechler R, Martínez-Llordella M, Lombardi G. Applicability, safety, and biological activity of regulatory T cell therapy in liver transplantation. Am J Transplant. 2020 Apr;20(4):1125-1136. doi: 10.1111/ajt.15700. Epub 2020 Feb 3. PubMed PMID: 31715056; PubMed Central PMCID: PMC7154724.
7.338
117
1
Safinia N, Vaikunthanathan T, Fraser H, Thirkell S, Lowe K, Blackmore L, Whitehouse G, Martinez-Llordella M, Jassem W, Sanchez-Fueyo A, Lechler RI, Lombardi G. Successful expansion of functional and stable regulatory T cells for immunotherapy in liver transplantation. Oncotarget. 2016 Feb 16;7(7):7563-77. doi: 10.18632/oncotarget.6927. PubMed PMID: 26788992; PubMed Central PMCID: PMC4884938.
107
Adams DH, Sanchez-Fueyo A, Samuel D. From immunosuppression to tolerance. J Hepatol. 2015 Apr;62(1 Suppl):S170-85. doi: 10.1016/j.jhep.2015.02.042. Review. PubMed PMID: 25920086.
20.582
104
1
Lozano JJ, Pallier A, Martinez-Llordella M, Danger R, López M, Giral M, Londoño MC, Rimola A, Soulillou JP, Brouard S, Sánchez-Fueyo A. Comparison of transcriptional and blood cell-phenotypic markers between operationally tolerant liver and kidney recipients. Am J Transplant. 2011 Sep;11(9):1916-26. doi: 10.1111/j.1600-6143.2011.03638.x. Epub 2011 Aug 9. PubMed PMID: 21827613.
7.338
98
1
Londoño MC, Rimola A, O'Grady J, Sanchez-Fueyo A. Immunosuppression minimization vs. complete drug withdrawal in liver transplantation. J Hepatol. 2013 Oct;59(4):872-9. doi: 10.1016/j.jhep.2013.04.003. Epub 2013 Apr 8. Review. PubMed PMID: 23578883.
20.582
77
1
Orlando G, Manzia T, Baiocchi L, Sanchez-Fueyo A, Angelico M, Tisone G. The Tor Vergata weaning off immunosuppression protocol in stable HCV liver transplant patients: the updated follow up at 78 months. Transpl Immunol. 2008 Nov;20(1-2):43-7. doi: 10.1016/j.trim.2008.08.007. Epub 2008 Sep 4. PubMed PMID: 18773958.
1.624
67
3
Bohne F, Londoño MC, Benítez C, Miquel R, Martínez-Llordella M, Russo C, Ortiz C, Bonaccorsi-Riani E, Brander C, Bauer T, Protzer U, Jaeckel E, Taubert R, Forns X, Navasa M, Berenguer M, Rimola A, Lozano JJ, Sánchez-Fueyo A. HCV-induced immune responses influence the development of operational tolerance after liver transplantation in humans. Sci Transl Med. 2014 Jun 25;6(242):242ra81. doi: 10.1126/scitranslmed.3008793. PubMed PMID: 24964989.
16.304
65
1
Taubert R, Danger R, Londoño MC, Christakoudi S, Martinez-Picola M, Rimola A, Manns MP, Sánchez-Fueyo A, Jaeckel E. Hepatic Infiltrates in Operational Tolerant Patients After Liver Transplantation Show Enrichment of Regulatory T Cells Before Proinflammatory Genes Are Downregulated. Am J Transplant. 2016 Apr;16(4):1285-93. doi: 10.1111/ajt.13617. Epub 2016 Feb 18. PubMed PMID: 26603835.
7.338
55
1
Thomson AW, Vionnet J, Sanchez-Fueyo A. Understanding, predicting and achieving liver transplant tolerance: from bench to bedside. Nat Rev Gastroenterol Hepatol. 2020 Aug 5. doi: 10.1038/s41575-020-0334-4. [Epub ahead of print] Review. PubMed PMID: 32759983.
29.869
54
1
Feng S, Bucuvalas JC, Mazariegos GV, Magee JC, Sanchez-Fueyo A, Spain KM, Lesniak A, Kanaparthi S, Perito E, Venkat VL, Burrell BE, Alonso EM, Bridges ND, Doo E, Gupta NA, Himes RW, Ikle D, Jackson AM, Lobritto SJ, Jose Lozano J, Martinez M, Ng VL, Rand EB, Sherker AH, Sundaram SS, Turmelle YP, Wood-Trageser M, Demetris AJ. Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Towards Personalized Management. Hepatology. 2020 Aug 12. doi: 10.1002/hep.31520. [Epub ahead of print] PubMed PMID: 32786149.
14.679
48
1
Harmon C, Sanchez-Fueyo A, O'Farrelly C, Houlihan DD. Natural Killer Cells and Liver Transplantation: Orchestrators of Rejection or Tolerance? Am J Transplant. 2016 Mar;16(3):751-7. doi: 10.1111/ajt.13565. Epub 2015 Dec 21. Review. PubMed PMID: 26690302.
7.338
47
1
Millán O, Benitez C, Guillén D, López A, Rimola A, Sánchez-Fueyo A, Brunet M. Biomarkers of immunoregulatory status in stable liver transplant recipients undergoing weaning of immunosuppressive therapy. Clin Immunol. 2010 Dec;137(3):337-46. doi: 10.1016/j.clim.2010.08.004. Epub 2010 Sep 6. PubMed PMID: 20822959.
3.368
42
3
Bonaccorsi-Riani E, Danger R, Lozano JJ, Martinez-Picola M, Kodela E, Mas-Malavila R, Bruguera M, Collins HL, Hider RC, Martinez-Llordella M, Sanchez-Fueyo A. Iron Deficiency Impairs Intra-Hepatic Lymphocyte Mediated Immune Response. PLoS One. 2015 Aug 19;10(8):e0136106. doi: 10.1371/journal.pone.0136106. eCollection 2015. PubMed PMID: 26287688; PubMed Central PMCID: PMC4542211.
2.74
42
2
Londoño MC, Danger R, Giral M, Soulillou JP, Sánchez-Fueyo A, Brouard S. A need for biomarkers of operational tolerance in liver and kidney transplantation. Am J Transplant. 2012 Jun;12(6):1370-7. doi: 10.1111/j.1600-6143.2012.04035.x. Epub 2012 Apr 4. Review. PubMed PMID: 22486792.
7.338
41
1
Levitsky J, Burrell BE, Kanaparthi S, Turka LA, Kurian S, Sanchez-Fueyo A, Lozano JJ, Demetris A, Lesniak A, Kirk AD, Stempora L, Yang GY, Mathew JM. Immunosuppression Withdrawal in Liver Transplant Recipients on Sirolimus. Hepatology. 2019 Nov 13. doi: 10.1002/hep.31036. [Epub ahead of print] PubMed PMID: 31721246; PubMed Central PMCID: PMC7217743.
14.679
38
1
Bonaccorsi-Riani E, Pennycuick A, Londoño MC, Lozano JJ, Benítez C, Sawitzki B, Martínez-Picola M, Bohne F, Martínez-Llordella M, Miquel R, Rimola A, Sánchez-Fueyo A. Molecular Characterization of Acute Cellular Rejection Occurring During Intentional Immunosuppression Withdrawal in Liver Transplantation. Am J Transplant. 2016 Feb;16(2):484-96. doi: 10.1111/ajt.13488. Epub 2015 Oct 30. PubMed PMID: 26517400.
7.338
34
1
Sánchez-Fueyo A. Hot-topic debate on tolerance: immunosuppression withdrawal. Liver Transpl. 2011 Nov;17 Suppl 3:S69-73. doi: 10.1002/lt.22421. PubMed PMID: 21850680.
4.57
34
1
Clavien PA, Muller X, de Oliveira ML, Dutkowski P, Sanchez-Fueyo A. Can immunosuppression be stopped after liver transplantation? Lancet Gastroenterol Hepatol. 2017 Jul;2(7):531-537. doi: 10.1016/S2468-1253(16)30208-4. Epub 2017 Mar 28. Review. PubMed PMID: 28606879.
14.789
31
1
Sánchez-Fueyo A, Strom TB. Immunological tolerance and liver transplantation. J Hepatol. 2004 Nov;41(5):698-705. Review. PubMed PMID: 15519640.
20.582
29
1
Whitehouse GP, Hope A, Sanchez-Fueyo A. Regulatory T-cell therapy in liver transplantation. Transpl Int. 2017 Aug;30(8):776-784. doi: 10.1111/tri.12998. Review. PubMed PMID: 28608637.
3.177
27
1
Vionnet J, Sánchez-Fueyo A. Biomarkers of immune tolerance in liver transplantation. Hum Immunol. 2018 May;79(5):388-394. doi: 10.1016/j.humimm.2018.02.010. Epub 2018 Feb 17. Review. PubMed PMID: 29462637.
2.412
27
3
Vionnet J, Miquel R, Abraldes JG, Wall J, Kodela E, Lozano JJ, Ruiz P, Navasa M, Marshall A, Nevens F, Gelson W, Leithead J, Masson S, Jaeckel E, Taubert R, Tachtatzis P, Eurich D, Simpson KJ, Bonaccorsi-Riani E, Feng S, Bucuvalas J, Ferguson J, Quaglia A, Sidorova J, Elstad M, Douiri A, Sánchez-Fueyo A. Non-invasive alloimmune risk stratification of long-term liver transplant recipients. J Hepatol. 2021 Aug 23. pii: S0168-8278(21)02001-8. doi: 10.1016/j.jhep.2021.08.007. [Epub ahead of print] PubMed PMID: 34437910.
20.582
20
Sánchez-Fueyo A. Identification of tolerant recipients following liver transplantation. Int Immunopharmacol. 2010 Dec;10(12):1501-4. doi: 10.1016/j.intimp.2010.06.011. Epub 2010 Jun 29. PubMed PMID: 20601182.
3.943
16
1
Vionnet J, Sempoux C, Pascual M, Sánchez-Fueyo A, Colmenero J. Donor-specific antibodies in liver transplantation. Gastroenterol Hepatol. 2020 Jan;43(1):34-45. doi: 10.1016/j.gastrohep.2019.09.010. Epub 2019 Dec 4. Review. English, Spanish. PubMed PMID: 31810796.
1.581
13
4
Tang Q, Leung J, Peng Y, Sanchez-Fueyo A, Lozano JJ, Lam A, Lee K, Greenland JR, Hellerstein M, Fitch M, Li KW, Esensten JH, Putnam AL, Lares A, Nguyen V, Liu W, Bridges ND, Odim J, Demetris AJ, Levitsky J, Taner T, Feng S. Selective decrease of donor-reactive T(regs) after liver transplantation limits T(reg) therapy for promoting allograft tolerance in humans. Sci Transl Med. 2022 Nov 2;14(669):eabo2628. doi: 10.1126/scitranslmed.abo2628. Epub 2022 Nov 2. PubMed PMID: 36322627.
19.319
11
Whitehouse GP, Sanchez-Fueyo A. Immunosuppression withdrawal following liver transplantation. Clin Res Hepatol Gastroenterol. 2014 Dec;38(6):676-80. doi: 10.1016/j.clinre.2014.06.011. Epub 2014 Oct 1. Review. PubMed PMID: 25281267.
2.718
11
3
Mastoridis S, Martínez-Llordella M, Sanchez-Fueyo A. Biomarkers and immunopathology of tolerance. Curr Opin Organ Transplant. 2016 Feb;21(1):81-7. doi: 10.1097/MOT.0000000000000269. Review. PubMed PMID: 26709578.
2.571
10
3
Mastoridis S, Martínez-Llordella M, Sanchez-Fueyo A. Emergent Transcriptomic Technologies and Their Role in the Discovery of Biomarkers of Liver Transplant Tolerance. Front Immunol. 2015 Jun 22;6:304. doi: 10.3389/fimmu.2015.00304. eCollection 2015. Review. PubMed PMID: 26157438; PubMed Central PMCID: PMC4476276.
5.085
9
1
Londoño MC, López MC, Sánchez-Fueyo A. Minimization of immunosuppression in adult liver transplantation: new strategies and tools. Curr Opin Organ Transplant. 2010 Dec;15(6):685-90. doi: 10.1097/MOT.0b013e3283402c55. Review. PubMed PMID: 20885324.
2.571
8
3
Montano-Loza AJ, Rodriguez-Peralvarez ML, Pageaux GP, Sanchez-Fueyo A, Feng S. Liver transplantation immunology: Immunosuppression, rejection, and immunomodulation. J Hepatol. 2023 Jun;78(6):1199-1215. doi: 10.1016/j.jhep.2023.01.030. PubMed PMID: 37208106.
30.083
6
Merritt E, Londoño MC, Childs K, Whitehouse G, Kodela E, Sánchez-Fueyo A, Martínez-Llordella M. On the impact of hepatitis C virus and heterologous immunity on alloimmune responses following liver transplantation. Am J Transplant. 2020 Jun 10. doi: 10.1111/ajt.16134. [Epub ahead of print] PubMed PMID: 32524678.
7.338
6
1
Dumontet E, Danger R, Vagefi PA, Londoño MC, Pallier A, Lozano JJ, Giral M, Degauque N, Soulillou JP, Martínez-Llordella M, Lee H, Latournerie M, Boudjema K, Dulong J, Tarte K, Sanchez-Fueyo A, Feng S, Brouard S, Conchon S. Peripheral phenotype and gene expression profiles of combined liver-kidney transplant patients. Liver Int. 2016 Mar;36(3):401-9. doi: 10.1111/liv.12917. Epub 2015 Aug 8. PubMed PMID: 26193627; PubMed Central PMCID: PMC5395096.
5.175
6
1
Donckier V, Sanchez-Fueyo A, Craciun L, Lucidi V, Buggenhout A, Troisi R, Rogiers X, Bourgeois N, Boon N, Moreno C, Colle I, Van Vlierberghe H, de Hemptinne B, Goldman M. Induction of tolerance in solid organ transplantation: the rationale to develop clinical protocols in liver transplantation. Transplant Proc. 2009 Mar;41(2):603-6. doi: 10.1016/j.transproceed.2009.01.040. PubMed PMID: 19328936.
0.784
6
4
Wood-Trageser MA, Lesniak D, Gambella A, Golnoski K, Feng S, Bucuvalas J, Sanchez-Fueyo A, Demetris AJ. Next-generation pathology detection of T cell-antigen-presenting cell immune synapses in human liver allografts. Hepatology. 2022 Jul 12. doi: 10.1002/hep.32666. [Epub ahead of print] PubMed PMID: 35819312.
17.298
4
Safinia N, Vaikunthanathan T, Lechler RI, Sanchez-Fueyo A, Lombardi G. Advances in Liver Transplantation: where are we in the pursuit of transplantation tolerance? Eur J Immunol. 2021 Aug 10. doi: 10.1002/eji.202048875. [Epub ahead of print] Review. PubMed PMID: 34375446.
4.404
4
Appenzeller-Herzog C, Rosat A, Mathes T, Baroja-Mazo A, Chruscinski A, Feng S, Herrero I, Londono MC, Mazariegos G, Ohe H, Pons JA, Sanchez-Fueyo A, Waki K, Vionnet J. Time since liver transplant and immunosuppression withdrawal outcomes: Systematic review and individual patient data meta-analysis. Liver Int. 2023 Oct 31. doi: 10.1111/liv.15764. Online ahead of print. PubMed PMID: 37905605.
6.7
0
Appenzeller-Herzog C, Rosat A, Mathes T, Baroja-Mazo A, Chruscinski A, Feng S, Herrero I, Londono MC, Mazariegos G, Ohe H, Pons JA, Sanchez-Fueyo A, Waki K, Vionnet J. Time since liver transplant and immunosuppression withdrawal outcomes: Systematic review and individual patient data meta-analysis. Liver Int. 2023 Oct 31. doi: 10.1111/liv.15764. Online ahead of print. PubMed PMID: 37905605.
6.7
0
Appenzeller-Herzog C, Rosat A, Mathes T, Baroja-Mazo A, Chruscinski A, Feng S, Herrero I, Londono MC, Mazariegos G, Ohe H, Pons JA, Sanchez-Fueyo A, Waki K, Vionnet J. Time since liver transplant and immunosuppression withdrawal outcomes: Systematic review and individual patient data meta-analysis. Liver Int. 2023 Oct 31. doi: 10.1111/liv.15764. Online ahead of print. PubMed PMID: 37905605.
6.7
0
Appenzeller-Herzog C, Rosat A, Mathes T, Baroja-Mazo A, Chruscinski A, Feng S, Herrero I, Londono MC, Mazariegos G, Ohe H, Pons JA, Sanchez-Fueyo A, Waki K, Vionnet J. Time since liver transplant and immunosuppression withdrawal outcomes: Systematic review and individual patient data meta-analysis. Liver Int. 2023 Oct 31. doi: 10.1111/liv.15764. Online ahead of print. PubMed PMID: 37905605.
6.7
0
Vionnet J, Sanchez-Fueyo A. Biomarkers of operational tolerance after liver transplantation: are we there yet? Liver Transpl. 2021 Aug 18. doi: 10.1002/lt.26270. [Epub ahead of print] PubMed PMID: 34407265.
4.57
0
Angelico R, Sensi B, Tisone G, Feng S, Roll GR, Herrero I, Bonaccorsi-Riani E, Pons JA, Ruiz P, Berenguer M, Den Hoed C, Mazariegos G, Smith R, Parente A, Aluvihare V, Sanchez-Fueyo A, Tan E, Calretas S, Lanari J, Spada M, Montano-Loza AJ, De Meijer VE, Pirenne J, Riley C, Chahal D, De Martin E, Di Sandro S, Patrono D, Garcia-Juarez I, Cachero A, Adali G, Ghinolfi D, Camagni S, Milla AA, Bayramov N, Elbahr O, Manzia TM, Rogers R, Mehdi T, Jakoubek D, Pascual M, Inarrairaegui M, Foguenne M, Ciccarelli O, Mazo AB, Romero PR, Colmenero J, Aguilera MV, Polak W, Lytvyak E, Glassey E, Rajoriya N, Muthiah M, Boccagni P, Blokzijl H, Rodriguez-Peralvarez M. Complete immunosuppression withdrawal after liver transplantation: An International Multicenter Study. Clin Gastroenterol Hepatol. 2026 Jun 9:S1542-3565(26)00410-6. doi: 10.1016/j.cgh.2026.05.027. Online ahead of print. PubMed PMID: 42263796.
12.0
Tanimine N, Markmann JF, Wood-Trageser MA, Demetris AJ, Mason K, Silva JAF, Levitsky J, Feng S, Humar A, Emond JC, Shaked A, Klintmalm G, Sanchez-Fueyo A, Lesniak D, Breeden CP, Nepom GT, Bridges ND, Goldstein J, Larsen CP, DesMarais M, Gaile G, Chandran S. Donor-specific Immune Senescence as a Candidate Biomarker of Operational Tolerance Following Liver Transplantation in Adults: Results of a Prospective, Multicenter Cohort Study. Am J Transplant. 2024 Nov 4:S1600-6135(24)00682-8. doi: 10.1016/j.ajt.2024.10.022. Online ahead of print. PubMed PMID: 39505152.
8.9
Vionnet J, Torres-Yaguana J, Miquel R, Abraldes JG, Wall J, Kodela E, Lozano JJ, Ruiz P, Navasa M, Marshall A, Nevens F, Gelson W, Leithead J, Masson S, Jaeckel E, Taubert R, Tachtatzis P, Eurich D, Simpson KJ, Bonaccorsi-Riani E, Ferguson J, Quaglia A, Demetris AJ, Lesniak AJ, Elstad M, Delord M, Douiri A, Rebollo-Mesa I, Martinez-Llordella M, Silva JAF, Markmann JF, Sanchez-Fueyo A. Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression. Am J Transplant. 2024 Dec 18:S1600-6135(24)00749-4. doi: 10.1016/j.ajt.2024.12.002. Online ahead of print. PubMed PMID: 39706366.
8.9
Vionnet J, Miquel R, Abraldes JG, Lozano JJ, Ruiz P, Navasa M, Marshall A, Nevens F, Gelson W, Leithead J, Masson S, Jaeckel E, Taubert R, Tachtatzis P, Eurich D, Simpson K, Bonaccorsi-Riani E, Ferguson J, Quaglia A, Elstad M, Delord M, Douiri A, Sanchez-Fueyo A. The clinical utility and safety of biomarker-guided immunosuppression withdrawal in liver transplantation: the LIFT prospective RCT. Southampton (UK): National Institute for Health and Care Research; 2025 Apr. Available from http://www.ncbi.nlm.nih.gov/books/NBK613563/ PubMed PMID: 40238953.
2.0
Sánchez-Fueyo A. [Immunological tolerance and liver transplantation]. Gastroenterol Hepatol. 2005 Apr;28(4):250-6. Review. Spanish. PubMed PMID: 15811269.
1.581
4
Mastoridis S, Martinez-Llordella M, Sanchez-Fueyo A. Extracellular vesicles as mediators of alloimmunity and their therapeutic potential in liver transplantation. World J Transplant. 2020 Nov 28;10(11):330-344. doi: 10.5500/wjt.v10.i11.330. Review. PubMed PMID: 33312894; PubMed Central PMCID: PMC7708876.

Data Sources

IMIB-Arrixaca

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Biomedical Informatics & Bioinformatics Platform
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