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Further information

TOLERANCE
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Thomson, Angus W


Publications

Impact Factor

Cites


ReferenceImpact FactorCitesQuartile
Qian S, Lu L, Fu F, Li Y, Li W, Starzl TE, Fung JJ, Thomson AW. Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction. J Immunol. 1997 May 15;158(10):4654-61. PubMed PMID: 9144477; PubMed Central PMCID: PMC2954768.
4.886
261
2
Thomson AW, Lu L, Murase N, Demetris AJ, Rao AS, Starzl TE. Microchimerism, dendritic cell progenitors and transplantation tolerance. Stem Cells. 1995 Nov;13(6):622-39. Review. PubMed PMID: 8590864; PubMed Central PMCID: PMC2963943.
6.022
158
1
Thomson AW, Lu L. Are dendritic cells the key to liver transplant tolerance? Immunol Today. 1999 Jan;20(1):27-32. Review. PubMed PMID: 10081227.
157
Mazariegos GV, Zahorchak AF, Reyes J, Ostrowski L, Flynn B, Zeevi A, Thomson AW. Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients. Am J Transplant. 2003 Jun;3(6):689-96. PubMed PMID: 12780560.
7.338
131
1
Tokita D, Mazariegos GV, Zahorchak AF, Chien N, Abe M, Raimondi G, Thomson AW. High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance. Transplantation. 2008 Feb 15;85(3):369-77. doi: 10.1097/TP.0b013e3181612ded. PubMed PMID: 18301333.
4.546
124
1
Ezzelarab M, Thomson AW. Tolerogenic dendritic cells and their role in transplantation. Semin Immunol. 2011 Aug;23(4):252-63. doi: 10.1016/j.smim.2011.06.007. Epub 2011 Jul 7. Review. PubMed PMID: 21741270; PubMed Central PMCID: PMC3192911.
9.186
123
1
Li W, Kuhr CS, Zheng XX, Carper K, Thomson AW, Reyes JD, Perkins JD. New insights into mechanisms of spontaneous liver transplant tolerance: the role of Foxp3-expressing CD25+CD4+ regulatory T cells. Am J Transplant. 2008 Aug;8(8):1639-51. doi: 10.1111/j.1600-6143.2008.02300.x. Epub 2008 Jun 12. PubMed PMID: 18557727.
7.338
116
1
Steptoe RJ, Fu F, Li W, Drakes ML, Lu L, Demetris AJ, Qian S, McKenna HJ, Thomson AW. Augmentation of dendritic cells in murine organ donors by Flt3 ligand alters the balance between transplant tolerance and immunity. J Immunol. 1997 Dec 1;159(11):5483-91. PubMed PMID: 9548488.
4.886
109
2
Mazariegos GV, Zahorchak AF, Reyes J, Chapman H, Zeevi A, Thomson AW. Dendritic cell subset ratio in tolerant, weaning and non-tolerant liver recipients is not affected by extent of immunosuppression. Am J Transplant. 2005 Feb;5(2):314-22. PubMed PMID: 15643991.
7.338
82
1
Sumpter TL, Abe M, Tokita D, Thomson AW. Dendritic cells, the liver, and transplantation. Hepatology. 2007 Dec;46(6):2021-31. Review. PubMed PMID: 18027875.
14.679
79
1
Mazariegos GV, Sindhi R, Thomson AW, Marcos A. Clinical tolerance following liver transplantation: long term results and future prospects. Transpl Immunol. 2007 Feb;17(2):114-9. Epub 2006 Oct 17. Review. PubMed PMID: 17306742.
1.624
69
3
Ono Y, Perez-Gutierrez A, Nakao T, Dai H, Camirand G, Yoshida O, Yokota S, Stolz DB, Ross MA, Morelli AE, Geller DA, Thomson AW. Graft-infiltrating PD-L1(hi) cross-dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance. Hepatology. 2018 Apr;67(4):1499-1515. doi: 10.1002/hep.29529. Epub 2018 Feb 18. PubMed PMID: 28921638; PubMed Central PMCID: PMC5856603.
14.679
66
1
Dangi A, Sumpter TL, Kimura S, Stolz DB, Murase N, Raimondi G, Vodovotz Y, Huang C, Thomson AW, Gandhi CR. Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. J Immunol. 2012 Apr 15;188(8):3667-77. doi: 10.4049/jimmunol.1102460. Epub 2012 Mar 16. PubMed PMID: 22427640; PubMed Central PMCID: PMC3328102.
4.886
63
2
Li W, Lu L, Wang Z, Wang L, Fung JJ, Thomson AW, Qian S. Il-12 antagonism enhances apoptotic death of T cells within hepatic allografts from Flt3 ligand-treated donors and promotes graft acceptance. J Immunol. 2001 May 1;166(9):5619-28. PubMed PMID: 11313402.
4.886
57
2
Morelli AE, O'Connell PJ, Khanna A, Logar AJ, Lu L, Thomson AW. Preferential induction of Th1 responses by functionally mature hepatic (CD8alpha- and CD8alpha+) dendritic cells: association with conversion from liver transplant tolerance to acute rejection. Transplantation. 2000 Jun 27;69(12):2647-57. PubMed PMID: 10910289.
4.546
55
1
Thomson AW, Vionnet J, Sanchez-Fueyo A. Understanding, predicting and achieving liver transplant tolerance: from bench to bedside. Nat Rev Gastroenterol Hepatol. 2020 Aug 5. doi: 10.1038/s41575-020-0334-4. [Epub ahead of print] Review. PubMed PMID: 32759983.
29.869
54
1
Demetris AJ, Lunz JG 3rd, Randhawa P, Wu T, Nalesnik M, Thomson AW. Monitoring of human liver and kidney allograft tolerance: a tissue/histopathology perspective. Transpl Int. 2009 Jan;22(1):120-41. doi: 10.1111/j.1432-2277.2008.00765.x. Epub 2008 Sep 26. Review. PubMed PMID: 18980624.
3.177
49
1
Castellaneta A, Mazariegos GV, Nayyar N, Zeevi A, Thomson AW. HLA-G level on monocytoid dendritic cells correlates with regulatory T-cell Foxp3 expression in liver transplant tolerance. Transplantation. 2011 May 27;91(10):1132-40. doi: 10.1097/TP.0b013e31821414c9. PubMed PMID: 21423069; PubMed Central PMCID: PMC3087844.
4.546
47
1
Thomson AW, Humar A, Lakkis FG, Metes DM. Regulatory dendritic cells for promotion of liver transplant operational tolerance: Rationale for a clinical trial and accompanying mechanistic studies. Hum Immunol. 2018 May;79(5):314-321. doi: 10.1016/j.humimm.2017.10.017. Epub 2017 Oct 31. Review. PubMed PMID: 29100944; PubMed Central PMCID: PMC5924712.
2.412
46
3
Li W, Carper K, Zheng XX, Kuhr CS, Reyes JD, Liang Y, Perkins DL, Thomson AW, Perkins JD. The role of Foxp3+ regulatory T cells in liver transplant tolerance. Transplant Proc. 2006 Dec;38(10):3205-6. PubMed PMID: 17175223.
0.784
44
4
Thomson AW, Drakes ML, Zahorchak AF, O'Connell PJ, Steptoe RJ, Qian S, Lu L. Hepatic dendritic cells: immunobiology and role in liver transplantation. J Leukoc Biol. 1999 Aug;66(2):322-30. Review. PubMed PMID: 10449176.
3.757
41
2
Yokota S, Yoshida O, Ono Y, Geller DA, Thomson AW. Liver transplantation in the mouse: Insights into liver immunobiology, tissue injury, and allograft tolerance. Liver Transpl. 2016 Apr;22(4):536-46. doi: 10.1002/lt.24394. Review. PubMed PMID: 26709949; PubMed Central PMCID: PMC4811737.
4.57
39
1
Li W, Carper K, Liang Y, Zheng XX, Kuhr CS, Reyes JD, Perkins DL, Thomson AW, Perkins JD. Anti-CD25 mAb administration prevents spontaneous liver transplant tolerance. Transplant Proc. 2006 Dec;38(10):3207-8. PubMed PMID: 17175224.
0.784
37
4
Natarajan S, Thomson AW. Tolerogenic dendritic cells and myeloid-derived suppressor cells: potential for regulation and therapy of liver auto- and alloimmunity. Immunobiology. 2010 Sep-Oct;215(9-10):698-703. doi: 10.1016/j.imbio.2010.05.024. Epub 2010 Jun 22. Review. PubMed PMID: 20605054; PubMed Central PMCID: PMC2918690.
2.788
35
3
Mazariegos GV, Reyes J, Webber SA, Thomson AW, Ostrowski L, Abmed M, Pillage G, Martell J, Awad MR, Zeevi A. Cytokine gene polymorphisms in children successfully withdrawn from immunosuppression after liver transplantation. Transplantation. 2002 Apr 27;73(8):1342-5. PubMed PMID: 11981433.
4.546
34
1
Girnita A, Mazariegos GV, Castellaneta A, Reyes J, Bentlejewski C, Thomson AW, Zeevi A. Liver transplant recipients weaned off immunosuppression lack circulating donor-specific antibodies. Hum Immunol. 2010 Mar;71(3):274-6. doi: 10.1016/j.humimm.2009.12.002. Epub 2009 Dec 23. PubMed PMID: 20006667.
2.412
33
3
Thomson AW, Mazariegos GV, Reyes J, Donnenberg VS, Donnenberg AD, Bentlejewski C, Zahorchak AF, O'Connell PJ, Fung JJ, Jankowska-Gan E, Burlingham WJ, Heeger PS, Zeevi A. Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients. Transplantation. 2001 Oct 27;72(8 Suppl):S13-22. Review. PubMed PMID: 11888150.
4.546
28
1
Macedo C, Tran L, Zahorchak AF, Dai H, Gu X, Ravichandran R, Mohanakumar T, Elinoff B, Zeevi A, Styn MA, Humar A, Lakkis FG, Metes DM, Thomson AW. Donor-derived regulatory dendritic cell infusion results in host cell cross-dressing and T cell subset changes in prospective living donor liver transplant recipients. Am J Transplant. 2020 Nov 10. doi: 10.1111/ajt.16393. [Epub ahead of print] PubMed PMID: 33171019.
7.338
26
1
Thomson AW, Ezzelarab MB. Regulatory dendritic cells: profiling, targeting, and therapeutic application. Curr Opin Organ Transplant. 2018 Oct;23(5):538-545. doi: 10.1097/MOT.0000000000000565. Review. PubMed PMID: 30036199; PubMed Central PMCID: PMC6620776.
2.571
23
3
Yokota S, Ueki S, Ono Y, Kasahara N, Pérez-Gutiérrez A, Kimura S, Yoshida O, Murase N, Yasuda Y, Geller DA, Thomson AW. Orthotopic mouse liver transplantation to study liver biology and allograft tolerance. Nat Protoc. 2016 Jul;11(7):1163-74. doi: 10.1038/nprot.2016.073. Epub 2016 Jun 2. PubMed PMID: 27254462.
3.902
21
Yoshida O, Kimura S, Dou L, Matta BM, Yokota S, Ross MA, Geller DA, Thomson AW. DAP12 deficiency in liver allografts results in enhanced donor DC migration, augmented effector T cell responses and abrogation of transplant tolerance. Am J Transplant. 2014 Aug;14(8):1791-805. doi: 10.1111/ajt.12757. Epub 2014 Jun 16. PubMed PMID: 24935196; PubMed Central PMCID: PMC4107008.
7.338
20
1
Dai H, Zheng Y, Thomson AW, Rogers NM. Transplant Tolerance Induction: Insights From the Liver. Front Immunol. 2020 Jun 5;11:1044. doi: 10.3389/fimmu.2020.01044. eCollection 2020. Review. PubMed PMID: 32582167; PubMed Central PMCID: PMC7289953.
5.085
20
1
Castellaneta A, Thomson AW, Nayyar N, de Vera M, Mazariegos GV. Monitoring the operationally tolerant liver allograft recipient. Curr Opin Organ Transplant. 2010 Feb;15(1):28-34. doi: 10.1097/MOT.0b013e328334269a. Review. PubMed PMID: 19890211.
2.571
19
3
Issa F, Strober S, Leventhal JR, Kawai T, Kaufman DB, Levitsky J, Sykes M, Mas V, Wood KJ, Bridges N, Welniak LA, Chandran S, Madsen JC, Nickerson P, Demetris AJ, Lakkis FG, Thomson AW. The Fourth International Workshop on Clinical Transplant Tolerance. Am J Transplant. 2020 Jun 12. doi: 10.1111/ajt.16139. [Epub ahead of print] PubMed PMID: 32529725.
7.338
17
1
Yoshida O, Dou L, Kimura S, Yokota S, Isse K, Robson SC, Geller DA, Thomson AW. CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection. Transpl Immunol. 2015 Mar;32(2):76-83. doi: 10.1016/j.trim.2015.01.003. Epub 2015 Feb 7. PubMed PMID: 25661084; PubMed Central PMCID: PMC4368493.
1.624
17
3
Steptoe RJ, Li W, Fu F, O'Connell PJ, Thomson AW. Trafficking of APC from liver allografts of Flt3L-treated donors: augmentation of potent allostimulatory cells in recipient lymphoid tissue is associated with a switch from tolerance to rejection. Transpl Immunol. 1999 Mar;7(1):51-7. PubMed PMID: 10375078.
1.624
16
3
Qian S, Lu L, Li Y, Fu F, Li W, Starzl TE, Thomson AW, Fung JJ. Apoptosis of graft-infiltrating cytotoxic T cells: a mechanism underlying "split tolerance" in mouse liver transplantation. Transplant Proc. 1997 Feb-Mar;29(1-2):1168-9. PubMed PMID: 9123257; PubMed Central PMCID: PMC2955444.
0.784
16
4
Nakano R, Tran LM, Geller DA, Macedo C, Metes DM, Thomson AW. Dendritic Cell-Mediated Regulation of Liver Ischemia-Reperfusion Injury and Liver Transplant Rejection. Front Immunol. 2021 Jun 28;12:705465. doi: 10.3389/fimmu.2021.705465. eCollection 2021. Review. PubMed PMID: 34262574; PubMed Central PMCID: PMC8273384.
5.085
10
Nakano R, Yoshida O, Kimura S, Nakao T, Yokota S, Ono Y, Minervini MI, Geller DA, Thomson AW. Donor plasmacytoid dendritic cells modulate effector and regulatory T cell responses in mouse spontaneous liver transplant tolerance. Am J Transplant. 2020 Nov 28. doi: 10.1111/ajt.16412. [Epub ahead of print] PubMed PMID: 33247989.
7.338
8
1
Zahorchak AF, DeRiggi ML, Muzzio JL, Sutherland V, Humar A, Lakkis FG, Hsu YS, Thomson AW. Manufacturing and validation of Good Manufacturing Practice-compliant regulatory dendritic cells for infusion into organ transplant recipients. Cytotherapy. 2023 Jan 11:S1465-3249(22)01026-X. doi: 10.1016/j.jcyt.2022.11.005. Online ahead of print. PubMed PMID: 36639251.
6.196
2
Tran LM, Macedo C, Zahorchak AF, Gu X, Elinoff B, Singhi AD, Isett B, Zeevi A, Sykes M, Breen K, Srivastava A, Ables EM, Landsittel D, Styn MA, Humar A, Lakkis FG, Metes DM, Thomson AW. Donor-derived regulatory dendritic cell infusion modulates effector CD8+ T cell and NK cell responses after liver transplantation. Sci Transl Med. 2023 Oct 11;15(717):eadf4287. doi: 10.1126/scitranslmed.adf4287. Epub 2023 Oct 11. PubMed PMID: 37820009.
17.1
0
Humar A, Hadjiyannis Y, Macedo C, Tran LM, Elinoff BD, Hughes CB, Ganesh SR, Zahorchak AF, Ables EM, Styn MA, Landsittel D, Zeevi A, Lakkis FG, Metes DM, Thomson AW. Donor-derived regulatory dendritic cell infusion and early immunosuppressive drug withdrawal in living-donor liver transplantation: a phase I/IIa trial. Nat Commun. 2026 Apr 17;17(1):3226. doi: 10.1038/s41467-026-71280-8. PubMed PMID: 41997912; PubMed Central PMCID: PMC13090339.
15.7
Humar A, Hadjiyannis Y, Macedo C, Tran LM, Elinoff BD, Hughes CB, Ganesh SR, Zahorchak AF, Ables EM, Styn MA, Landsittel D, Zeevi A, Lakkis FG, Metes DM, Thomson AW. Donor-derived regulatory dendritic cell infusion and early immunosuppressive drug withdrawal in living-donor liver transplantation: a phase I/IIa trial. Nat Commun. 2026 Apr 17;17(1):3226. doi: 10.1038/s41467-026-71280-8. PubMed PMID: 41997912; PubMed Central PMCID: PMC13090339.
15.7
Yokota S, Li W, Clavien PA, Kupiec-Weglinski JW, Thomson AW. Mouse orthotopic liver transplantation: Challenges, achievements, and applications. Am J Transplant. 2025 Sep;25(9):1830-1842. doi: 10.1016/j.ajt.2025.06.011. Epub 2025 Jun 14. PubMed PMID: 40523479.
8.9
Elsabbagh AM, Hadjiyannis Y, Vionnet J, Thomson AW. Clinical and Experimental Immune Tolerance in Pediatric Liver Transplantation. Pediatr Transplant. 2026 Jan;30(1):e70260. doi: 10.1111/petr.70260. PubMed PMID: 41500616.
1.4

Data Sources

PubMed
NCBI
SemanticScholar
Web of Science
Human Phenotype ontology
KEGG
IMIB-Arrixaca

Address

Biomedical Informatics & Bioinformatics Platform
Institute for Bio-health Research of Murcia (IMIB-Arrixaca)
Carretera Buenavista s/n, 30120
El Palmar, Murcia, Spain

E-mail

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