Bismuth H, Samuel D, Castaing D, Williams R, Pereira SP
Approximately 11% of all liver transplants performed in Europe are for acute liver failure, with one-year patient survival rates ranging between 50% and 75%. This review summarizes the selection, perioperative management, and outcome of patients transplanted for acute liver failure, with particular reference to the experience at the Hopital Paul Brousse in Paris and at King's College Hospital, London. In both centers, the decision to proceed to liver transplantation is based on criteria that predict a survival of less than 20% with medical management alone. Infectious complications and cerebral edema remain the most common causes of death, and highlight the importance of intensive monitoring and early treatment of perioperative complications. In selected patients, auxiliary partial orthotopic liver transplantation may be a therapeutic option, with the potential for native liver generation and eventual immunosuppression withdrawal in approximately two-thirds of patients.
01/11/1996
9027954
Seminars in liver disease (
IF: 4.457 /
Quartile: 2)
WOS Cites: 116
SemanticScholar Cites: 124
SemanticScholar Citation Velocity: 0
SemanticScholar Influential Citation Count: 4
